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Two isostructural, solution-stable tetra-antimony(III)-containing 18-tungsto-2-arsenates(V), [(LSbIII)4(A-α-AsVW9O34)2]10− (L = Ph (1), OH (2)), have been synthesized and structurally characterized. Both polyanions are solution-stable in physiological medium, but they exhibit distinctly different biological activity, which can be attributed to the different tetra-antimony(III) motifs (PhSbIII vs HOSbIII) in an otherwise isostructural polyanion framework. We presume that the presence of organic functionalities in 1 is responsible for the highly efficient antibacterial activity of this polyanion as compared to its fully inorganic analogue 2.
Two tetra-antimony(III)-bridged, sandwich-type 18-tungsto-2-arsenates(V), [(LSbIII)4(A-α-AsVW9O34)2]10– (L = Ph (1), OH (2)), were prepared and fully characterized in the solid state and in solution. Both polyanions are stable in aqueous physiological medium for at least 24 h (at concentrations ≥2.5 × 10–6 M). Despite the presence of an isostructural tetra-antimony(III) motif in 1 and 2, distinctly different antibacterial activity was observed for both polyanions. The minimum inhibitory concentrations (MIC) of 1 (7.8–62.5 μg/mL) is lower than for any other organoantimony(III)-containing polyoxometalate reported to date.
|حجم فایل||547 B|